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KMID : 0368820200590020166
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Journal of the Korean Neuropsychiatr Association
2020 Volume.59 No. 2 p.166 ~ p.169
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Worsening of Psychotic Symptoms in Patients with Chronic Schizophrenia after Switching to or Combining Aripiprazole and Aripiprazole Monthly (Abilify Maintena)
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Park Myeong-Hyun Michelle
Kim Su-Ryong
Hahm Woong
Paik In-Ho
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Abstract
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Objectives: Aripiprazole is an antipsychotic that functions as a partial agonist in hypodopaminergic states and a dopamine antagonist in hyperdopaminergic states.
Methods: This paper reports a series of five clinical cases of worsening psychotic symptoms in schizophrenic patients related to the initiation of aripiprazole, oral and injection, as combination therapy.
Results: In all five cases, the switching of aripiprazole improved the psychotic symptoms.
Conclusion: Even with the suggestive relationship between aripiprazole therapy and the worsening of psychotic symptoms, further research is needed.
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KEYWORD
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Schizophrenia, Aripiprazole, Combination therapy
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